CALL FOR PAPERS Comparative Genomics Negative energy balance alters global gene expression and immune responses in the uterus of postpartum dairy cows
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چکیده
D. Claire Wathes, Zhangrui Cheng, Waliul Chowdhury, Mark A. Fenwick, Richard Fitzpatrick, Dermot G. Morris, Joe Patton, and John J. Murphy Reproduction Group, Department of Veterinary Basic Sciences, Royal Veterinary College, London, United Kingdom; Animal Production Research Centre, Mellows Campus, Athenry, County Galway; and Teagasc Moorepark, Dairy Production Research Centre, Fermoy, County Cork, Ireland
منابع مشابه
Negative energy balance alters global gene expression and immune responses in the uterus of postpartum dairy cows
Most dairy cows suffer uterine microbial contamination postpartum. Persistent endometritis often develops, associated with reduced fertility. We used a model of differential feeding and milking regimes to produce cows in differing negative energy balance status in early lactation (mild or severe, MNEB or SNEB). Blood hematology was assessed preslaughter at 2 wk postpartum. RNA expression in end...
متن کاملPleiotropic effects of negative energy balance in the postpartum dairy cow on splenic gene expression: repercussions for innate and adaptive immunity
Increased energy demands to support lactation, coupled with lowered feed intake capacity results in negative energy balance (NEB) and is typically characterized by extensive mobilization of body energy reserves in the early postpartum dairy cow. The catabolism of stored lipid leads to an increase in the systemic concentrations of nonesterified fatty acids (NEFA) and beta-hydroxy butyrate (BHB)....
متن کاملNegative energy balance and hepatic gene expression patterns in high-yielding dairy cows during the early postpartum period: a global approach
In high-yielding dairy cows the liver undergoes extensive physiological and biochemical changes during the early postpartum period in an effort to re-establish metabolic homeostasis and to counteract the adverse effects of negative energy balance (NEB). These adaptations are likely to be mediated by significant alterations in hepatic gene expression. To gain new insights into these events an en...
متن کاملCALL FOR PAPERS Epigenetics and Epigenomics Modulation of the immune system during postpartum uterine inflammation
Walker CG, Meier S, Hussein H, McDougall S, Burke CR, Roche JR, Mitchell MD. Modulation of the immune system during postpartum uterine inflammation. Physiol Genomics 47: 89–101, 2015. First published January 20, 2015; doi:10.1152/physiolgenomics.00098.2014.— Postpartum uterine inflammation (endometritis) in the dairy cow is associated with lower fertility at both the time of infection and after...
متن کاملModulation of the immune system during postpartum uterine inflammation.
Postpartum uterine inflammation (endometritis) in the dairy cow is associated with lower fertility at both the time of infection and after the inflammation has resolved. We hypothesized that aberrant DNA methylation may be involved in the subfertility associated with uterine inflammation. The objective of this study was to characterize genome-wide DNA methylation and gene expression in the endo...
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تاریخ انتشار 2009